Response to zinc ion

Across TCGA patient cohorts, RNA activity of the Response to zinc ion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNMT1, NCAPD3, and BMP8A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to zinc ion activity versus DNMT1 in UCEC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DNMT1 →	-0.520	-0.195	<.001	.002	3	4
OV	NCAPD3 →	-0.615	-0.281	.001	.001	3	4
HNSC	BMP8A →	+0.609	+0.144	.003	.001	3	4
LSCC	KNSTRN →	-0.527	-0.157	<.001	<.001	3	4
GBM	PKDREJ →	+0.304	+0.127	.001	.009	3	4
LSCC	SMC2 →	-0.569	-0.180	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010043 vs DNMT1 — UCEC

Explore this scatter interactively →