Response to zinc ion

Across TCGA pan-cancer cohorts, RNA activity of the Response to zinc ion pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 51 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Response to zinc ion pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SARC and MESO, show the opposite pattern, with higher activity associated with better survival.

UCEC, LGG, and SARC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.822	0.932	<.001	50	view →
LGG	OS	Median	All	0.325	0.525	<.001	45	view →
SARC	OS	Quartile	All	0.694	0.378	.001	25	view →
KIRC	DFS	Tertile	II,III,IV	0.490	0.718	.006	24	view →
MESO	DFS	Tertile	All	0.457	0.259	.008	24	view →
GBM	OS	Median	All	0.294	0.538	.003	21	view →
SCLC	DFS	Median	III,IV	0.338	0.968	.024	20	view →
ESCA	OS	Tertile	III,IV	0.661	0.292	.010	18	view →
COAD	OS	Tertile	III,IV	0.405	0.809	.015	11	view →
LUSC	OS	Quartile	III,IV	0.709	0.283	.017	8	view →
THYM	DFS	Tertile	All	0.523	0.918	.031	5	view →
THCA	OS	Quartile	III,IV	0.934	1.000	.018	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0010043–UCEC (OS)

Open the UCEC breakdown →