Response to iron ion

Across TCGA patient cohorts, RNA activity of the Response to iron ion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAI2, HYKK, and MCM7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to iron ion activity versus RAI2 in HNSC (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RAI2 →	+0.725	+0.184	<.001	<.001	3	5
HNSC	HYKK →	+0.406	+0.166	<.001	<.001	3	5
COAD	MCM7 →	-0.475	-0.175	.002	.008	3	4
HNSC	CHST10 →	+0.627	+0.145	.001	.003	3	4
HNSC	CORIN →	+0.649	+0.127	<.001	.005	3	4
LSCC	CDCA5 →	-0.675	-0.162	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010039 vs RAI2 — HNSC

Explore this scatter interactively →