Meiotic chromosome condensation

Across TCGA patient cohorts, RNA activity of the Meiotic chromosome condensation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCNB2, CDC25C, and SKA3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Meiotic chromosome condensation activity versus CCNB2 in BRCA (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCNB2 →	+1.024	+1.078	<.001	<.001	3	7
OV	CDC25C →	+1.190	+0.606	<.001	.006	3	7
UCEC	SKA3 →	+1.120	+1.288	<.001	<.001	3	7
UCEC	SEPTIN14P12 →	+0.672	+0.637	.001	<.001	3	7
BRCA	UBE2T →	+0.988	+0.943	<.001	<.001	3	7
UCEC	ESCO2 →	+0.654	+0.635	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010032 vs CCNB2 — BRCA

Explore this scatter interactively →