Anterior/posterior pattern specification

Across TCGA patient cohorts, RNA activity of the Anterior/posterior pattern specification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHD6, CROCCP3, and DSTYK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterior/posterior pattern specification activity versus CHD6 in UCEC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHD6 →	+0.703	+0.513	.002	.007	3	5
UCEC	CROCCP3 →	+0.424	+0.527	.002	.001	3	5
HNSC	DSTYK →	+0.445	+0.302	.009	.004	3	4
CCRCC	ZDHHC17 →	+0.245	+0.306	.003	.005	2	5
HNSC	ZKSCAN3 →	+0.476	+0.284	<.001	<.001	3	4
CCRCC	LYRM9 →	+0.334	+0.327	.008	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009952 vs CHD6 — UCEC

Explore this scatter interactively →