Anterior/posterior pattern specification

Across TCGA pan-cancer cohorts, RNA activity of the Anterior/posterior pattern specification pathway is associated with patient survival in 20 of 34 cancer lineages. Pathway activity is summarized from the expression of its 219 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Anterior/posterior pattern specification pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and LGG, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRP, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	All	0.321	0.802	<.001	89	view →
KIRP	OS	Median	All	0.417	0.792	<.001	53	view →
UCS	DFS	Quartile	II,III,IV	0.592	0.150	.002	46	view →
LGG	OS	Tertile	All	0.880	0.733	<.001	41	view →
LIHC	DFS	Tertile	All	0.311	0.482	.002	36	view →
CESC	OS	Tertile	III,IV	0.593	0.883	.010	32	view →
THYM	DFS	Median	II,III,IV	0.959	0.756	.004	22	view →
HNSC	DFS	Median	IV	0.735	0.579	.003	16	view →
READ	DFS	Median	IV	0.214	0.760	<.001	15	view →
ESCA	OS	Median	III,IV	0.569	0.342	.033	13	view →
KIRC	DFS	Median	IV	0.331	0.748	<.001	13	view →
DLBC	OS	Tertile	II,III,IV	0.520	1.000	.013	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

GO:0009952–ACC (OS)

Open the ACC breakdown →