Anterior/posterior pattern specification

Across TCGA cell cohorts, RNA activity of the Anterior/posterior pattern specification pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM156B, RNF115, and STXBP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM156B grouped by Anterior/posterior pattern specification-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	FAM156B →	+0.704	+1.019	.001	<.001	3	3
OVARY	RNF115 →	-0.617	-0.959	<.001	.005	2	4
URINARY_TRACT	STXBP6 →	-3.630	-1.654	.001	<.001	3	3
PANCREAS	CDKN2C →	-1.751	-0.759	<.001	.006	3	3
BONE	SMAD7 →	-1.234	-1.001	.001	.006	3	3
BONE	MAN1A1 →	-3.660	-1.589	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM156B by Anterior/posterior pattern specification activity — KIDNEY

Explore this box plot interactively →