Dorsal/ventral axis specification

Across TCGA patient cohorts, RNA activity of the Dorsal/ventral axis specification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SPON1, SFRP1, and CENPV, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dorsal/ventral axis specification activity versus SPON1 in GBM (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPON1 →	+0.831	+0.054	.003	.002	3	5
LSCC	SFRP1 →	+0.717	+0.046	<.001	<.001	3	5
LSCC	CENPV →	+0.480	+0.039	<.001	.002	3	5
UCEC	LRRC20 →	+0.275	+0.074	.004	<.001	3	5
GBM	MGAT1 →	-0.401	-0.067	<.001	<.001	3	5
PDAC	ITGA7 →	+0.497	+0.068	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009950 vs SPON1 — GBM

Explore this scatter interactively →