Dorsal/ventral axis specification

Across TCGA cell cohorts, RNA activity of the Dorsal/ventral axis specification pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SDF2, PPP1R13L, and MPP7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SDF2 grouped by Dorsal/ventral axis specification-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SDF2 →	-0.652	-1.291	<.001	<.001	3	4
BLOOD_Myeloma	PPP1R13L →	-1.815	-1.537	.003	.005	3	4
BLOOD_Lymphoma	MPP7 →	+0.913	+1.969	.002	<.001	3	4
LUNG_SCLC	EIF2B4 →	-0.458	-1.399	.006	.004	3	4
LUNG_SCLC	KCNJ14 →	-0.714	-1.402	.004	.003	3	4
CNS	MFSD4B →	-0.421	-0.924	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SDF2 by Dorsal/ventral axis specification activity — OVARY

Explore this box plot interactively →