Catechol-containing compound biosynthetic process

Across TCGA patient cohorts, RNA activity of the Catechol-containing compound biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZNF148, UBXN7, and RFC4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Catechol-containing compound biosynthetic process activity versus ZNF148 in OV (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZNF148 →	-0.269	-0.047	<.001	.001	3	6
LSCC	UBXN7 →	-0.595	-0.092	<.001	<.001	3	6
LSCC	RFC4 →	-0.321	-0.077	<.001	<.001	3	5
BRCA	ASL →	+0.443	+0.052	<.001	<.001	3	5
GBM	SETDB1 →	-0.263	-0.111	<.001	<.001	3	5
CCRCC	RAB3IP →	+0.476	+0.096	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009713 vs ZNF148 — OV

Explore this scatter interactively →