Phenylpropanoid metabolic process

Across TCGA patient cohorts, RNA activity of the Phenylpropanoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD2_S168, MYO1E, and TNRC6B_S879, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenylpropanoid metabolic process activity versus AMPD2_S168 in HNSC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AMPD2_S168 →	-0.333	-0.641	.004	.001	3	5
HNSC	MYO1E →	-0.247	-0.515	<.001	.001	3	5
PDAC	TNRC6B_S879 →	+0.471	+0.435	.007	.008	3	5
PDAC	MAOA →	+0.392	+0.513	.002	.004	3	5
LSCC	LSM7 →	+0.146	+0.444	<.001	<.001	3	5
GBM	RCN3 →	-0.520	-0.433	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009698 vs AMPD2_S168 — HNSC

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