Phenylpropanoid metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Phenylpropanoid metabolic process pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 7 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Phenylpropanoid metabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and UCEC, show the opposite pattern, with higher activity associated with better survival.

HNSC, UCEC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.871	0.684	<.001	76	view →
UCEC	DFS	Tertile	All	0.936	0.843	<.001	52	view →
LGG	DFS	Median	All	0.807	0.673	<.001	50	view →
LUSC	OS	Quartile	All	0.739	0.573	.008	43	view →
KIRC	DFS	Tertile	II,III,IV	0.381	0.611	.004	34	view →
LUAD	OS	Median	All	0.425	0.309	.005	33	view →
COAD	DFS	Median	II,III,IV	0.577	0.371	.011	25	view →
ESCA	DFS	Quartile	III,IV	0.213	0.525	<.001	23	view →
LIHC	OS	Tertile	III,IV	0.857	0.414	.001	21	view →
READ	DFS	Quartile	II,III,IV	0.311	0.662	.010	20	view →
GBM	OS	Quartile	All	0.501	0.232	.022	15	view →
UVM	DFS	Tertile	All	0.701	0.275	.019	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0009698–HNSC (OS)

Open the HNSC breakdown →