Phenylpropanoid metabolic process

Across TCGA patient cohorts, RNA activity of the Phenylpropanoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRODH, MIOX, and SDR39U1, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phenylpropanoid metabolic process activity versus PRODH in LSCC (Pearson r = 0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PRODH →	+1.193	+0.355	<.001	.003	2	1
LSCC	MIOX →	+2.125	+0.355	.005	.003	2	1
LSCC	SDR39U1 →	+0.828	+0.355	<.001	.003	2	1
LSCC	AHSA1 →	+0.841	+0.355	<.001	.003	2	1
LSCC	SLC6A13 →	+1.830	+0.355	.007	.003	2	1
LSCC	EEF1D →	+0.988	+0.355	.008	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009698 vs PRODH — LSCC

Explore this scatter interactively →