Response to salt stress

Across TCGA patient cohorts, RNA activity of the Response to salt stress pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLEKHA1, EPB41L1_T475, and LPIN3_S411, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to salt stress activity versus PLEKHA1 in GBM (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PLEKHA1 →	+0.667	+0.112	<.001	<.001	3	5
GBM	EPB41L1_T475 →	+0.563	+0.059	<.001	<.001	3	5
LSCC	LPIN3_S411 →	+0.609	+0.055	<.001	.002	3	4
LSCC	NECTIN4 →	+0.526	+0.055	.007	<.001	2	5
CCRCC	SIN3A →	-0.133	-0.060	.006	.004	3	4
CCRCC	SNX27 →	+0.112	+0.048	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009651 vs PLEKHA1 — GBM

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