Response to gravity

Across TCGA cell cohorts, RNA activity of the Response to gravity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LNPK, BTG3, and HOXB4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LNPK grouped by Response to gravity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LNPK →	+0.476	+0.759	.009	.003	2	5
SKIN	BTG3 →	+0.892	+1.149	.002	.002	3	4
BLOOD_Myeloma	HOXB4 →	+1.628	+1.488	.001	.002	3	4
BLOOD_Lymphoma	ETFA →	-0.756	-2.010	.008	.001	2	4
BLOOD_Lymphoma	MMP14 →	+1.237	+1.609	.005	.007	3	3
BREAST	GPANK1 →	-0.623	-1.136	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LNPK by Response to gravity activity — SKIN

Explore this box plot interactively →