7-methylguanosine RNA capping

Across TCGA patient cohorts, RNA activity of the 7-methylguanosine RNA capping pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NCBP3, STIM1_S257, and EEA1_S52, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 7-methylguanosine RNA capping activity versus NCBP3 in LUAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NCBP3 →	+0.304	+0.056	<.001	<.001	3	6
LUAD	STIM1_S257 →	-0.584	-0.047	.003	<.001	3	5
CCRCC	EEA1_S52 →	-0.586	-0.026	<.001	<.001	3	5
LUAD	TNKS1BP1_S244 →	-0.546	-0.062	<.001	<.001	3	4
LSCC	YTHDC1 →	+0.223	+0.038	<.001	.001	3	4
LSCC	ZNF638 →	+0.273	+0.044	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009452 vs NCBP3 — LUAD

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