7-methylguanosine RNA capping

Across TCGA pan-cancer cohorts, RNA activity of the 7-methylguanosine RNA capping pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher 7-methylguanosine RNA capping pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and THYM, show the opposite pattern, with higher activity associated with better survival.

LGG, SKCM, and CESC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Tertile	All	0.386	0.598	<.001	41	view →
SKCM	DFS	Median	II,III,IV	0.191	0.319	.001	40	view →
CESC	DFS	Quartile	All	0.758	0.860	.023	24	view →
READ	OS	Quartile	II,III,IV	1.000	0.427	.001	24	view →
DLBC	DFS	Tertile	All	0.550	0.947	.004	18	view →
OV	OS	Median	III,IV	0.631	0.728	.013	16	view →
KIRC	DFS	Tertile	II,III,IV	0.307	0.610	.007	13	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.490	.021	12	view →
GBM	DFS	Tertile	All	0.448	0.217	.008	12	view →
COAD	DFS	Quartile	All	0.390	0.584	.018	9	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	9	view →
MESO	DFS	Median	IV	0.217	0.504	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0009452–LGG (OS)

Open the LGG breakdown →