7-methylguanosine RNA capping

Across TCGA patient cohorts, RNA activity of the 7-methylguanosine RNA capping pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN3, CDCA7L, and NEMP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 7-methylguanosine RNA capping activity versus CDKN3 in UCEC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDKN3 →	+0.702	+0.241	.002	.006	3	6
GBM	CDCA7L →	+0.626	+0.291	.005	.004	3	5
HNSC	NEMP1 →	+0.574	+0.255	.006	.005	3	5
GBM	AURKB →	+0.737	+0.317	.009	.003	3	5
LSCC	BRIP1 →	+0.623	+0.181	.001	.001	3	5
UCEC	NUF2 →	+1.028	+0.324	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009452 vs CDKN3 — UCEC

Explore this scatter interactively →