7-methylguanosine RNA capping

Across TCGA cell cohorts, RNA activity of the 7-methylguanosine RNA capping pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACBD5, NFE2L2, and RPS27L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 7-methylguanosine RNA capping activity versus ACBD5 in OESOPHAGUS (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ACBD5 →	-1.381	-1.578	<.001	<.001	3	4
PANCREAS	NFE2L2 →	-0.675	-0.904	.001	.004	3	4
OVARY	RPS27L →	-1.199	-0.589	.002	.006	3	4
PANCREAS	MIER1 →	-0.471	-1.092	.006	.007	3	4
BLOOD_Leukemia	CARD10 →	-0.696	-0.902	<.001	<.001	3	4
BLOOD_Leukemia	TMEM144 →	-1.227	-0.869	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009452 vs ACBD5 — OESOPHAGUS

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