Gamma-aminobutyric acid metabolic process

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ALDH5A1, ABAT, and ALDH1A1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid metabolic process activity versus ALDH5A1 in COAD (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ALDH5A1 →	+0.627	+0.078	<.001	<.001	3	8
BRCA	ABAT →	+0.752	+0.047	<.001	<.001	3	6
HNSC	ALDH1A1 →	+0.739	+0.123	.001	<.001	3	6
HNSC	BRD7 →	+0.185	+0.089	<.001	<.001	3	5
PDAC	CMTR1 →	+0.214	+0.060	.001	<.001	3	5
GBM	THNSL1 →	+0.311	+0.112	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009448 vs ALDH5A1 — COAD

Explore this scatter interactively →