Oligosaccharide metabolic process

Across TCGA patient cohorts, RNA activity of the Oligosaccharide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP1, BMS1, and PES1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligosaccharide metabolic process activity versus TOP1 in LSCC (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOP1 →	-0.338	-0.037	.002	<.001	3	8
GBM	BMS1 →	-0.240	-0.037	.004	<.001	3	8
LSCC	PES1 →	-0.270	-0.024	<.001	<.001	3	8
LSCC	PDCD11 →	-0.339	-0.033	<.001	<.001	3	8
OV	WDR43_S77 →	-0.813	-0.034	.007	<.001	3	7
COAD	TOP2A_S1247 →	-0.664	-0.022	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009311 vs TOP1 — LSCC

Explore this scatter interactively →