Pyrimidine ribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTCP1, MED28, and POLA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTCP1 grouped by Pyrimidine ribonucleotide catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MTCP1 →	+0.793	+0.846	.003	.005	3	5
LUNG_NSCLC_LUSC	MED28 →	-1.169	-1.446	.008	.006	3	5
STOMACH	POLA2 →	+0.885	+1.574	.004	<.001	2	6
LIVER	SH2B3 →	+2.038	+1.895	.001	<.001	3	5
CNS	NABP2 →	+0.555	+0.931	<.001	.001	3	4
OESOPHAGUS	SASH1 →	-1.373	-1.235	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTCP1 by Pyrimidine ribonucleotide catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →