Deoxyribonucleoside monophosphate metabolic process

pathway activity — cross-omics
GO:0009162Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRM2, SMC4, and SPC24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCRRM2 →+0.587+0.060<.001<.00135
LSCCSMC4 →+0.456+0.047<.001.00135
LSCCSPC24 →+0.510+0.061<.001<.00135
OVSIPA1 →+0.248+0.043.001<.00135
LUADUPP1 →+0.684+0.057<.001<.00135
OVMYO1E →+0.321+0.030<.001.00935
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration