Pyrimidine nucleoside diphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAP1GAP2, PARP9, and STK25, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside diphosphate biosynthetic process activity versus RAP1GAP2 in UCEC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RAP1GAP2 →	-0.806	-0.231	<.001	<.001	3	5
GBM	PARP9 →	+0.456	+0.120	.008	.002	3	5
COAD	STK25 →	-0.362	-0.144	<.001	<.001	3	4
COAD	SH3BP4 →	-0.589	-0.129	<.001	.002	3	4
COAD	NCKIPSD →	-0.581	-0.141	<.001	.006	3	4
BRCA	RGL2 →	-0.730	-0.166	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009139 vs RAP1GAP2 — UCEC

Explore this scatter interactively →