Pyrimidine nucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTHFD1L, RTKN2, and IL7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside monophosphate catabolic process activity versus MTHFD1L in BLOOD_Lymphoma (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MTHFD1L →	-0.814	-0.806	<.001	.004	3	4
BLOOD_Lymphoma	RTKN2 →	-1.500	-0.925	<.001	.003	3	4
CNS	IL7 →	-1.426	-0.943	<.001	<.001	3	4
LUNG_NSCLC_LUSC	RNF113A →	-0.986	-1.866	.008	<.001	3	4
BLOOD_Leukemia	HACL1 →	-0.644	-0.911	.002	.003	3	4
CNS	STUB1 →	-0.804	-1.209	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009131 vs MTHFD1L — BLOOD_Lymphoma

Explore this scatter interactively →