Pyrimidine nucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside monophosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A, SMC4, and MCM2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside monophosphate biosynthetic process activity versus TOP2A in LSCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TOP2A →	+0.966	+0.061	<.001	<.001	3	8
GBM	SMC4 →	+0.405	+0.035	<.001	<.001	3	8
GBM	MCM2 →	+0.656	+0.050	<.001	<.001	3	8
GBM	MCM6 →	+0.715	+0.048	<.001	<.001	3	8
LSCC	WDR75 →	+0.249	+0.040	<.001	<.001	3	8
LSCC	RRM2 →	+0.644	+0.070	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009130 vs TOP2A — LSCC

Explore this scatter interactively →