Vitamin biosynthetic process

Across TCGA patient cohorts, RNA activity of the Vitamin biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP27A1, ICOS, and GIMAP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vitamin biosynthetic process activity versus CYP27A1 in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CYP27A1 →	+0.763	+0.144	<.001	.002	3	5
LSCC	ICOS →	+0.610	+0.341	.001	.002	3	5
LSCC	GIMAP5 →	+0.517	+0.301	<.001	.001	3	5
GBM	APBB1IP →	+0.795	+0.195	<.001	<.001	3	5
OV	RNF125 →	+0.633	+0.147	<.001	.004	2	6
LSCC	SPOCK2 →	+0.801	+0.415	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009110 vs CYP27A1 — BRCA

Explore this scatter interactively →