Aromatic amino acid family catabolic process

Across TCGA patient cohorts, RNA activity of the Aromatic amino acid family catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GIMAP8, GIMAP7, and GBP4, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid family catabolic process activity versus GIMAP8 in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP8 →	+0.783	+0.169	<.001	<.001	3	8
HNSC	GIMAP7 →	+0.971	+0.131	<.001	<.001	3	8
OV	GBP4 →	+1.281	+0.258	<.001	<.001	3	7
UCEC	TRGC2 →	+0.883	+0.183	<.001	<.001	3	7
GBM	CCL4 →	+1.318	+0.151	<.001	<.001	3	7
UCEC	TRG-AS1 →	+0.648	+0.208	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009074 vs GIMAP8 — HNSC

Explore this scatter interactively →