GO:0009074Ontology (GO BP)GO biological process · ~16 member genes
Q-omics provides the Aromatic amino acid family catabolic process (GO:0009074) pathway profile, scoring each patient from the combined activity of its roughly 16 member genes. Pathway activity is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in LIHC. Among the 18 cancer types available for tumor–normal comparison, the pathway is differentially active in 7, with the highest sampling consensus in KIRP. Additionally, pathway RNA activity shows 30,817 significant cross-omics associations, again with the highest sampling consensus in BRCA. Together, these results highlight LIHC, KIRP, and BRCA as cancer lineages where the pathway shows reproducible signals across outcome, tissue activity, and molecular association analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns. Pathway-against-pathway and pathway-against-mutation comparisons are not available for ontology entities.
Survival associations
This table summarizes Aromatic amino acid family catabolic process survival associations by molecular data type. RNA-level pathway activity shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each layer.
This table ranks reproducible pathway activity–survival associations across cancer types. High Aromatic amino acid family catabolic process activity shows favorable associations in LIHC, UVM, OV and DLBC, but unfavorable associations in UCS and COAD. In the LIHC Kaplan–Meier curve the low-activity group declines faster, consistent with the favorable association (log-rank p < 0.001). LIHC ranks highest by sampling consensus for Aromatic amino acid family catabolic process.
This table summarizes Aromatic amino acid family catabolic process tumor–normal activity differences by data type. RNA-level activity shows significant tumor–normal differences in 7 cancer types, while mass-spec protein activity shows differences in 5. The strongest signals are in KIRP for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal activity differences for the pathway. A positive fold-change indicates higher activity in tumor tissue. The pathway shows higher tumor activity across READ and lower tumor activity in KIRP, LIHC, KICH, THCA and CHOL. In the KIRP box plot, normal samples show higher pathway activity than tumor samples (log2 FC = −0.123, t-test p < 0.001).
This table shows molecular features associated with Aromatic amino acid family catabolic process pathway activity in patient tissues and cancer cell lines. In patient samples, pathway activity is most strongly linked to RNA and protein features, with the largest associated set in BRCA. In cancer cell lines, RNA-expression features and functional dependencies dominate, with the largest set in LIVER.
