Aromatic amino acid family catabolic process

Across TCGA cell cohorts, RNA activity of the Aromatic amino acid family catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNN, SLC44A2, and LRCH4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aromatic amino acid family catabolic process activity versus SNN in OVARY (Pearson r = -0.85).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SNN →	-1.400	-1.961	.008	<.001	3	4
BLOOD_Lymphoma	SLC44A2 →	-2.241	-1.388	<.001	.001	3	4
BLOOD_Lymphoma	LRCH4 →	-0.770	-1.126	.001	.002	3	3
BLOOD_Lymphoma	DOP1A →	-1.038	-1.586	.001	.001	3	3
LUNG_NSCLC_LUAD	RABGAP1L →	-1.311	-1.315	<.001	<.001	3	3
SKIN	CPM →	+2.010	+1.322	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009074 vs SNN — OVARY

Explore this scatter interactively →