Serine family amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Serine family amino acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHGDH, PSPH, and UNG, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serine family amino acid biosynthetic process activity versus PHGDH in LSCC (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PHGDH →	+0.625	+0.057	<.001	<.001	3	8
HNSC	PSPH →	+0.733	+0.087	<.001	<.001	3	8
HNSC	UNG →	+0.440	+0.085	<.001	<.001	3	7
LUAD	PSAT1 →	+0.600	+0.051	.003	.003	3	7
BRCA	SHMT1 →	+0.439	+0.033	<.001	.003	2	7
LSCC	WDR12 →	+0.374	+0.048	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009070 vs PHGDH — LSCC

Explore this scatter interactively →