Phospholipid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Phospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP25, SNORD113-3, and CNEP1R1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid biosynthetic process activity versus USP25 in OV (Pearson r = 0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	USP25 →	+1.133	+0.224	<.001	.005	3	3
OV	SNORD113-3 →	+1.580	+0.195	<.001	.008	3	2
OV	CNEP1R1 →	+0.654	+0.236	.005	.008	3	2
OV	H2BP2 →	+0.355	+0.273	.002	.003	3	2
OV	HMGA1P4 →	+1.645	+0.246	.004	.003	3	2
BRCA	HERPUD2 →	+0.615	+0.274	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008654 vs USP25 — OV

Explore this scatter interactively →