Phospholipid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Phospholipid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR19, FAM171A2, and COL7A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipid biosynthetic process activity versus PRR19 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRR19 →	+1.257	+0.162	.006	.004	3	4
OVARY	FAM171A2 →	+1.599	+1.294	.003	<.001	3	4
BLOOD_Lymphoma	COL7A1 →	-1.977	-0.192	<.001	<.001	3	4
OVARY	PLXNB1 →	+1.569	+1.006	.001	.003	3	3
OVARY	TTC27 →	-0.483	-0.815	.001	.003	3	3
OVARY	STK10 →	-1.011	-0.901	.007	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008654 vs PRR19 — STOMACH

Explore this scatter interactively →