Amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Amino acid biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLR3, DNTTIP2, and HMGB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid biosynthetic process activity versus TLR3 in BRCA (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TLR3 →	+0.445	+0.025	.001	.001	3	5
GBM	DNTTIP2 →	-0.190	-0.025	.002	.001	3	5
OV	HMGB1 →	-0.388	-0.033	.007	<.001	3	5
OV	LMNB2 →	-0.458	-0.034	.002	<.001	3	5
CCRCC	LYPLAL1 →	+0.237	+0.042	<.001	<.001	3	5
CCRCC	PLCD1 →	-0.227	-0.026	.002	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008652 vs TLR3 — BRCA

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