Amino acid biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Amino acid biosynthetic process pathway differs between tumor and matched normal tissue in 11 of the 18 cancer types tested.

The strongest signal is observed in kidney chromophobe (KICH), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as KICH and THCA, show the opposite pattern, with lower activity in tumor tissue.

KICH, THCA, and LUAD show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
KICH	Female	II,III,IV	−0.079	<.001	11	view →
THCA	Male	III,IV	−0.052	<.001	10	view →
LUAD	Male	All	+0.035	<.001	7	view →
BRCA	All	All	−0.020	<.001	6	view →
CHOL	Male	All	−0.066	<.001	4	view →
KIRP	Male	All	−0.038	<.001	4	view →
KIRC	Male	All	−0.017	<.001	4	view →
COAD	Female	All	−0.022	.001	3	view →
STAD	Male	II,III,IV	+0.030	.036	2	view →
HNSC	All	III,IV	+0.016	.010	2	view →
LUSC	All	All	+0.013	.006	2	view →

Pink = more active in tumor, green = less active in tumor. Showing the 11 strongest of 11 lineages.

GO:0008652–KICH

Open the KICH breakdown →