Amino acid biosynthetic process

Across TCGA pan-cancer cohorts, RNA activity of the Amino acid biosynthetic process pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 77 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Amino acid biosynthetic process pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as MESO and SKCM, show the opposite pattern, with higher activity associated with better survival.

LGG, CHOL, and UVM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.650	0.797	<.001	48	view →
CHOL	DFS	Tertile	II,III,IV	0.060	0.441	<.001	41	view →
UVM	DFS	Tertile	II,III,IV	0.299	0.680	.006	30	view →
KIRC	OS	Median	II,III,IV	0.419	0.584	.018	28	view →
MESO	OS	Tertile	All	0.648	0.419	.006	27	view →
LUSC	OS	Quartile	III,IV	0.317	0.888	.012	27	view →
THCA	OS	Quartile	II,III,IV	0.777	0.958	.009	26	view →
COAD	DFS	Median	III,IV	0.509	0.736	.003	24	view →
KIRP	DFS	Quartile	All	0.468	0.890	<.001	22	view →
HNSC	OS	Tertile	All	0.615	0.840	.004	19	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	14	view →
STAD	DFS	Median	IV	0.097	0.412	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0008652–LGG (DFS)

Open the LGG breakdown →