Amino acid biosynthetic process

Across TCGA patient cohorts, RNA activity of the Amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, POLA2, and MKI67, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amino acid biosynthetic process activity versus NCAPH in UCEC (Pearson r = -0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPH →	-0.627	-0.208	<.001	<.001	3	5
UCEC	POLA2 →	-0.461	-0.227	.001	<.001	3	5
UCEC	MKI67 →	-0.619	-0.145	.002	.004	3	5
GBM	ABAT →	+0.622	+0.124	.001	<.001	3	5
PDAC	ZSCAN22 →	-0.168	-0.113	.002	.003	3	5
PDAC	MAST2 →	-0.213	-0.128	.006	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008652 vs NCAPH — UCEC

Explore this scatter interactively →