Amino acid biosynthetic process

Across TCGA cell cohorts, RNA activity of the Amino acid biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SOGA1, BCL2L1, and NEPRO, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SOGA1 grouped by Amino acid biosynthetic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SOGA1 →	-0.903	-0.580	.005	.004	3	6
LUNG_SCLC	BCL2L1 →	-1.185	-0.543	<.001	.002	3	3
KIDNEY	NEPRO →	-0.724	-1.041	<.001	.007	3	3
OVARY	SAMD9L →	-1.144	-0.564	.003	.004	3	3
OVARY	RPL31 →	+0.636	+0.535	<.001	.007	3	3
PANCREAS	HELZ2 →	-0.863	-0.981	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SOGA1 by Amino acid biosynthetic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →