Attachment of spindle microtubules to kinetochore

Across TCGA patient cohorts, RNA activity of the Attachment of spindle microtubules to kinetochore pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC2, RFC4, and RPL12_S38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Attachment of spindle microtubules to kinetochore activity versus RFC2 in UCEC (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RFC2 →	+0.423	+0.178	<.001	<.001	3	10
LSCC	RFC4 →	+0.476	+0.078	<.001	<.001	3	10
LUAD	RPL12_S38 →	+1.384	+0.146	<.001	<.001	3	10
GBM	RRM1 →	+0.409	+0.106	<.001	<.001	3	10
LUAD	RRM2 →	+1.055	+0.160	<.001	<.001	3	10
GBM	SMC2 →	+0.785	+0.154	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008608 vs RFC2 — UCEC

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