Attachment of spindle microtubules to kinetochore

Across TCGA pan-cancer cohorts, RNA activity of the Attachment of spindle microtubules to kinetochore pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 49 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Attachment of spindle microtubules to kinetochore pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as READ and HNSC, show the opposite pattern, with higher activity associated with better survival.

ACC, KIRC, and KIRP are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.311	0.803	<.001	155	view →
KIRC	DFS	Median	All	0.487	0.715	<.001	152	view →
KIRP	OS	Median	All	0.551	0.761	<.001	146	view →
KICH	DFS	Tertile	All	0.593	1.000	<.001	124	view →
MESO	OS	Median	All	0.395	0.656	<.001	108	view →
THCA	DFS	Tertile	All	0.741	0.898	<.001	92	view →
LUAD	OS	Median	All	0.283	0.428	<.001	83	view →
LIHC	DFS	Median	All	0.444	0.623	<.001	82	view →
LGG	OS	Median	All	0.707	0.904	<.001	54	view →
UVM	DFS	Quartile	III,IV	0.155	0.781	<.001	49	view →
CHOL	OS	Tertile	All	0.325	0.942	<.001	41	view →
READ	OS	Quartile	All	0.869	0.299	<.001	35	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0008608–ACC (DFS)

Open the ACC breakdown →