Regulation of smoothened signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of smoothened signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRP4, KLLN, and UBAP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRP4 grouped by Regulation of smoothened signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRP4 →	-2.124	-0.217	<.001	.001	3	5
BLOOD_Lymphoma	KLLN →	-0.971	-0.184	<.001	.006	3	4
OESOPHAGUS	UBAP1 →	-0.725	-0.161	.004	.004	3	4
STOMACH	HOMER2 →	-1.795	-0.153	.007	.004	3	4
STOMACH	NUDCD2 →	-0.901	-0.224	.001	.001	3	4
LUNG_SCLC	KIF21B →	-1.841	-0.242	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRP4 by Regulation of smoothened signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →