Germ cell migration

Across TCGA patient cohorts, RNA activity of the Germ cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CXADR, RRP8, and SFRP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Germ cell migration activity versus CXADR in GBM (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CXADR →	+0.729	+0.069	<.001	<.001	3	5
BRCA	RRP8 →	-0.226	-0.077	.003	.002	3	4
BRCA	SFRP1 →	+0.941	+0.103	<.001	<.001	3	4
BRCA	SNTB1_S389 →	+0.349	+0.063	.004	.001	3	4
BRCA	TMOD1 →	+0.880	+0.136	<.001	<.001	3	4
BRCA	CDC42EP1 →	+0.391	+0.094	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008354 vs CXADR — GBM

Explore this scatter interactively →