Glucocorticoid metabolic process

Across TCGA patient cohorts, RNA activity of the Glucocorticoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPH, CENPA, and RACGAP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucocorticoid metabolic process activity versus NCAPH in GBM (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NCAPH →	-0.873	-0.195	.001	<.001	3	6
BRCA	CENPA →	-0.811	-0.124	.001	.003	3	6
LSCC	RACGAP1 →	-0.929	-0.832	<.001	<.001	3	6
LSCC	CHAF1A →	-0.831	-0.704	<.001	.008	3	6
GBM	MAD2L1 →	-0.767	-0.167	.001	.001	3	6
GBM	MCM4 →	-0.682	-0.151	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008211 vs NCAPH — GBM

Explore this scatter interactively →