Glucocorticoid metabolic process

Across TCGA patient cohorts, RNA activity of the Glucocorticoid metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RRP1, DDX27, and GAS7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucocorticoid metabolic process activity versus RRP1 in BRCA (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RRP1 →	-0.533	-0.250	<.001	<.001	3	4
BRCA	DDX27 →	-0.388	-0.144	<.001	<.001	3	4
GBM	GAS7 →	+0.465	+0.125	<.001	.005	3	4
BRCA	RCL1 →	-0.282	-0.160	<.001	<.001	3	4
GBM	ZWILCH →	-0.518	-0.156	<.001	<.001	3	4
LUAD	NPM1_S70 →	-0.806	-0.142	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008211 vs RRP1 — BRCA

Explore this scatter interactively →