Glucocorticoid metabolic process

Across TCGA cell cohorts, RNA activity of the Glucocorticoid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA7A, FERMT1, and SLC20A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glucocorticoid metabolic process activity versus SEMA7A in STOMACH (Pearson r = -0.96).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SEMA7A →	-2.406	-0.523	.005	.007	3	3
LARGE_INTESTINE	FERMT1 →	+1.420	+0.332	.004	.006	3	2
LARGE_INTESTINE	SLC20A1 →	-1.144	-0.315	.001	.007	3	2
LARGE_INTESTINE	SUCO →	-0.848	-0.350	.003	.007	2	3
STOMACH	CD22 →	-3.020	-0.608	.004	.006	3	2
STOMACH	ICAM1 →	-2.093	-0.523	.005	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008211 vs SEMA7A — STOMACH

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