Bile acid metabolic process

Across TCGA cell cohorts, RNA activity of the Bile acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTIF, MAN2B2, and CCDC181, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CTIF grouped by Bile acid metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CTIF →	-0.964	-1.262	.007	<.001	3	5
PANCREAS	MAN2B2 →	-1.046	-1.228	.004	.004	2	5
CNS	CCDC181 →	+1.253	+1.182	<.001	<.001	3	4
LIVER	ARPC3 →	-0.500	-1.303	.002	<.001	3	4
LIVER	ANGPTL4 →	-2.250	-1.591	.003	<.001	2	5
SOFT_TISSUE	HLA-E →	-1.304	-1.333	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CTIF by Bile acid metabolic process activity — OVARY

Explore this box plot interactively →