Axo-dendritic transport

Across TCGA patient cohorts, RNA activity of the Axo-dendritic transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP1A, CLCNKB, and KIF20B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axo-dendritic transport activity versus MAP1A in LSCC (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1A →	+0.758	+0.338	<.001	<.001	3	5
OV	CLCNKB →	+0.498	+0.165	.006	<.001	3	3
BRCA	KIF20B →	-0.591	-0.152	.002	.001	3	3
BRCA	CDCA4 →	-0.662	-0.219	<.001	<.001	3	3
BRCA	IGHV4-59 →	-1.256	-0.113	.005	.002	3	3
LSCC	GLRB →	+0.713	+0.334	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008088 vs MAP1A — LSCC

Explore this scatter interactively →