Toll signaling pathway

Across TCGA cell cohorts, RNA activity of the Toll signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF10A, MTMR6, and VEZF1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Toll signaling pathway activity versus TNFRSF10A in SKIN (Pearson r = -0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TNFRSF10A →	-2.743	-0.421	.005	.005	3	3
SKIN	MTMR6 →	+0.960	+0.437	.001	.006	3	3
BLOOD_Leukemia	VEZF1 →	+0.956	+1.256	<.001	.007	3	3
CNS	WTIP →	+2.198	+1.784	<.001	.001	3	3
BLOOD_Leukemia	COPS7B →	+0.703	+1.631	<.001	<.001	3	3
BLOOD_Leukemia	DENND6A →	+0.873	+1.393	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0008063 vs TNFRSF10A — SKIN

Explore this scatter interactively →