Chemosensory behavior

Across TCGA patient cohorts, RNA activity of the Chemosensory behavior pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNBP1, SEPTIN1, and DENND1C_S596, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chemosensory behavior activity versus FNBP1 in UCEC (Pearson r = -0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FNBP1 →	-0.396	-0.058	.004	.001	3	6
BRCA	SEPTIN1 →	-0.576	-0.051	<.001	<.001	3	5
LSCC	DENND1C_S596 →	-0.648	-0.064	.001	.001	3	5
LSCC	IL16 →	-0.482	-0.080	<.001	<.001	3	5
COAD	MAP4K1 →	-0.476	-0.042	<.001	.001	3	5
LSCC	RAPGEF1 →	-0.265	-0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007635 vs FNBP1 — UCEC

Explore this scatter interactively →