Chemosensory behavior

Across TCGA cell cohorts, RNA activity of the Chemosensory behavior pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2BW2, AANAT, and DDX60, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2BW2 grouped by Chemosensory behavior-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	H2BW2 →	-0.204	-0.821	.006	.004	3	3
LUNG_SCLC	AANAT →	-0.144	-0.748	.006	.005	3	3
SOFT_TISSUE	DDX60 →	-0.151	-0.042	.001	.005	3	3
BONE	MORF4L1 →	+0.203	+0.156	.003	.003	3	3
BONE	MBP →	+0.157	+0.173	.008	.002	3	3
STOMACH	SCGB2B2 →	-0.128	-0.100	.006	.003	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2BW2 by Chemosensory behavior activity — LUNG_SCLC

Explore this box plot interactively →